MYH9

MYH9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LNK, 3ZWH, 4CFQ, 4CFR, 4ETO
Identifiers
Aliases	MYH9, BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA, myosin, heavy chain 9, non-muscle, myosin heavy chain 9
External IDs	MGI: 107717 HomoloGene: 129835 GeneCards: MYH9
Gene ontology Molecular function • protein homodimerization activity • nucleotide binding • microfilament motor activity • protein binding • ADP binding • protein anchor • actin-dependent ATPase activity • calmodulin binding • ATPase activity • protein domain specific binding • actin filament binding • actin binding • motor activity • ATP binding • RNA binding • cadherin binding Cellular component • myosin II filament • cell cortex • brush border • actomyosin • myosin complex • integrin complex • ruffle • nucleus • cell leading edge • protein complex • actomyosin contractile ring • cytoskeleton • cleavage furrow • cortical cytoskeleton • actin cytoskeleton • spindle • membrane • COP9 signalosome • extracellular exosome • neuromuscular junction • cytoplasm • cytosol • focal adhesion • plasma membrane • stress fiber • uropod • immunological synapse • myosin II complex • extracellular matrix • cell-cell adherens junction Biological process • in utero embryonic development • protein transport • monocyte differentiation • uropod organization • cell adhesion • cell morphogenesis involved in differentiation • platelet formation • leukocyte migration • cytokinesis • establishment of meiotic spindle localization • blood vessel endothelial cell migration • establishment of T cell polarity • myoblast fusion • membrane protein ectodomain proteolysis • actomyosin structure organization • angiogenesis • integrin-mediated signaling pathway • actin cytoskeleton reorganization • regulation of cell shape • actin filament-based movement • platelet aggregation • single organismal cell-cell adhesion • meiotic spindle organization • phagocytosis, engulfment • negative regulation of actin filament severing • positive regulation of protein processing in phagocytic vesicle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4627	17886
Ensembl	ENSG00000100345	ENSMUSG00000022443
UniProt	P35579 Q5BKV1	Q8VDD5
RefSeq (mRNA)	NM_002473	NM_022410
RefSeq (protein)	NP_002464 NP_002464.1	NP_071855.2 NP_071855
Location (UCSC)	Chr 22: 36.28 – 36.39 Mb	Chr 15: 77.76 – 77.84 Mb
PubMed search

2LNK, 3ZWH, 4CFQ, 4CFR, 4ETO

4627

17886

ENSG00000100345

ENSMUSG00000022443

P35579
Q5BKV1

Q8VDD5

NM_002473

NM_022410

NP_002464
NP_002464.1

NP_071855.2
NP_071855

Myosin, heavy chain 9, non-muscle is a protein which in humans is encoded by the MYH9 gene.

MYH9 polymorphisms have been shown to associate with glomerulosclerosis and non-diabetic end stage renal disease in African Americans and in Hispanic Americans, though it was later shown that two independent variants in the nearby APOL1 gene were responsible for the increased risk of disease.

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Wikipedia