MYB (gene)

MYB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GUU, 1GV2, 1GV5, 1GVD, 1H88, 1H89, 1IDY, 1IDZ, 1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK, 1MSE, 1MSF, 1SB0, 2AGH
Identifiers
Aliases	MYB, Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor
External IDs	MGI: 97249 HomoloGene: 31311 GeneCards: MYB
Genetically Related Diseases
Obesity
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • transcription factor activity, RNA polymerase II transcription factor recruiting • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • nuclear matrix • nucleus Biological process • positive regulation of transcription, DNA-templated • chromatin remodeling • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • positive regulation of histone H3-K4 methylation • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of histone H3-K9 methylation • positive regulation of T-helper cell differentiation • transcription from RNA polymerase II promoter • mitotic cell cycle • response to hypoxia • positive regulation of collagen biosynthetic process • positive regulation of neuron apoptotic process • positive regulation of smooth muscle cell proliferation • positive regulation of glial cell proliferation • cellular response to hydrogen peroxide • cellular response to retinoic acid • positive regulation of transforming growth factor beta production • positive regulation of neuron death • positive regulation of hepatic stellate cell proliferation • positive regulation of hepatic stellate cell activation • positive regulation of testosterone secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4602	17863
Ensembl	ENSG00000118513	ENSMUSG00000019982
UniProt	P10242 Q708E1	P06876
RefSeq (mRNA)	NM_001130172 NM_001130173 NM_001161656 NM_001161657 NM_001161658 NM_001161659 NM_001161660 NM_005375	NM_001198914 NM_010848 NM_033597
RefSeq (protein)	NP_001123644 NP_001123645 NP_001155128 NP_001155129 NP_001155130 NP_001155131 NP_001155132 NP_005366	NP_001185843.1 NP_034978.3 NP_001185843 NP_034978
Location (UCSC)	Chr 6: 135.18 – 135.22 Mb	Chr 10: 21.12 – 21.16 Mb
PubMed search

1GUU, 1GV2, 1GV5, 1GVD, 1H88, 1H89, 1IDY, 1IDZ, 1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK, 1MSE, 1MSF, 1SB0, 2AGH

4602

17863

ENSG00000118513

ENSMUSG00000019982

P10242
Q708E1

...
Wikipedia