MYBPC2

MYBPC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E7C, 2EDK, 2EDN
Identifiers
Aliases	MYBPC2, MYBPC, MYBPCF, myosin binding protein C, fast type
External IDs	MGI: 1336170 HomoloGene: 3331 GeneCards: MYBPC2
Gene ontology Molecular function • actin binding • structural constituent of muscle • protein binding • actin filament binding • muscle alpha-actinin binding • structural molecule activity conferring elasticity Cellular component • myosin filament • cytosol • muscle myosin complex • Z disc • M band Biological process • cell adhesion • muscle contraction • muscle filament sliding • striated muscle contraction • actin filament organization • sarcomere organization • striated muscle myosin thick filament assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4606	233199
Ensembl	ENSG00000086967	ENSMUSG00000038670
UniProt	Q14324	Q5XKE0
RefSeq (mRNA)	NM_004533	NM_146189
RefSeq (protein)	NP_004524	NP_666301.2 NP_666301
Location (UCSC)	Chr 19: 50.43 – 50.47 Mb	Chr 7: 44.5 – 44.52 Mb
PubMed search

2E7C, 2EDK, 2EDN

4606

233199

ENSG00000086967

ENSMUSG00000038670

Q14324

Q5XKE0

NM_004533

NM_146189

NP_004524

NP_666301.2
NP_666301

Myosin binding protein C, fast type is a protein that in humans is encoded by the MYBPC2 gene.

This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively.

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