MUTYH

MUTYH

Protein MUTYH PDB 1x51.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1X51, 3N5N

Identifiers

MUTYH, mutY homolog, MYH, mutY DNA glycosylase

External IDs

OMIM: 604933 MGI: 1917853 HomoloGene: 8156 GeneCards: MUTYH

Gene ontology
Molecular function	• MutSalpha complex binding • metal ion binding • hydrolase activity, acting on glycosyl bonds • hydrolase activity • catalytic activity • iron-sulfur cluster binding • MutLalpha complex binding • 4 iron, 4 sulfur cluster binding • MutLbeta complex binding • MutSbeta complex binding • protein binding • DNA N-glycosylase activity • DNA binding • purine-specific mismatch base pair DNA N-glycosylase activity
Cellular component	• nucleoplasm • mitochondrion • nucleus
Biological process	• DNA repair • metabolic process • depurination • cellular response to DNA damage stimulus • mismatch repair • base-excision repair
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE MUTYH 207727 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


4595


70603


ENSG00000132781


ENSMUSG00000028687


Q9UIF7


Q99P21

RefSeq (mRNA)

NM_001048171 NM_001048172 NM_001048173 NM_001048174 NM_001128425
NM_001293190 NM_001293191 NM_001293192 NM_001293195 NM_001293196 NM_012222


NM_001159581 NM_133250 NM_001316747

RefSeq (protein)

NP_001041636 NP_001041637 NP_001041638 NP_001041639 NP_001121897
NP_001280119 NP_001280120 NP_001280121 NP_001280124 NP_001280125 NP_036354 NP_001280121.1 NP_001280125.1


NP_001153053.1 NP_573513.2 NP_001153053 NP_001303676 NP_573513

Location (UCSC)

Chr 1: 45.33 – 45.34 Mb

Chr 4: 116.81 – 116.82 Mb

PubMed search

ENSG00000132781

ENSMUSG00000028687

NM_001293190
NM_001293191
NM_001293192
NM_001293195
NM_001293196
NM_012222

NM_001159581
NM_133250
NM_001316747

NP_001280119
NP_001280120
NP_001280121
NP_001280124
NP_001280125
NP_036354
NP_001280121.1
NP_001280125.1

...
Wikipedia

...