Juanes: MTV Unplugged is the third live album of Colombian singer Juanes. It was recorded before a live audience at the New World Symphony Center in Miami Beach, Florida, on February 1, 2012 and was released by Universal Music Latino on May 29, 2012. The album includes featured performances by the Spanish composer Joaquín Sabina and the Brazilian singer Paula Fernandes. The album features rearranged takes on Juanes' hit songs like "Me Enamora", La Camisa Negra and "A Dios le Pido". The first single of the live album was released on March 5, 2012 called La Señal, which became a hit in Latin America. The second single was "Me Enamora", with new instrumental arrangements, and was released two days after of the album's release. The album featured three new songs, one of which was a collaboration with Joaquín Sabina. The album debuted at number one on the Billboard Top Latin Albums Chart and won the 2012 Latin Grammy for Album of the Year. This was the third time he won Album of the Year at the Latin Grammys.

Following the release of his previous album, P.A.R.C.E. (2010), Juanes embarked on a tour to promote the album. However, the tour was canceled in the United States on May 2011 following the separation with his former manager Fernán Martínez, who labeled his last album a commercial failure, and the desire to spend time with his family. Martínez also affirmed that Juanes was experiencing depression and personal problems and would retire for a few years which Juanes's wife denied. On December 2011, Juanes announced that he would record a live album as part of the MTV Unplugged series. He stated the months he spent with his family was "a time of importance to strengthen my inner reflection and to come back with the desire and love I've always had to music."

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