MTMR3

MTMR3
Identifiers
Aliases	MTMR3, FYVE-DSP1, ZFYVE10, myotubularin related protein 3
External IDs	MGI: 1921552 HomoloGene: 23662 GeneCards: MTMR3
EC number	3.1.3.95
Gene ontology Molecular function • phosphoprotein phosphatase activity • metal ion binding • protein tyrosine phosphatase activity • hydrolase activity • protein binding • protein serine/threonine phosphatase activity • phosphatidylinositol-3-phosphatase activity • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Cellular component • cytoplasm • cytosol • membrane • extrinsic component of membrane • nucleoplasm Biological process • cellular response to glucose starvation • lipid metabolic process • protein dephosphorylation • regulation of autophagosome assembly • phosphatidylinositol dephosphorylation • phosphatidylinositol biosynthetic process • macroautophagy • dephosphorylation • peptidyl-tyrosine dephosphorylation • phosphatidylinositol 5-phosphate metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8897	74302
Ensembl	ENSG00000100330	ENSMUSG00000034354
UniProt	Q13615	Q8K296
RefSeq (mRNA)	NM_001013676 NM_021090 NM_153050 NM_153051	NM_028860
RefSeq (protein)	NP_066576 NP_694690 NP_694691 NP_694691.1	NP_083136
Location (UCSC)	Chr 22: 29.88 – 30.03 Mb	Chr 11: 4.48 – 4.59 Mb
PubMed search

8897

74302

ENSG00000100330

ENSMUSG00000034354

Q13615

Q8K296

NM_001013676
NM_021090
NM_153050
NM_153051

NM_028860

NP_066576
NP_694690
NP_694691
NP_694691.1

NP_083136

Myotubularin-related protein 3 is a protein that in humans is encoded by the MTMR3 gene.

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.

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