MTMR2

MTMR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LW3, 1M7R, 1ZSQ, 1ZVR
Identifiers
Aliases	MTMR2, CMT4B, CMT4B1, myotubularin related protein 2
External IDs	MGI: 1924366 HomoloGene: 22951 GeneCards: MTMR2
EC number	3.1.3.64
Gene ontology Molecular function • protein homodimerization activity • phosphatase activity • protein binding • protein tyrosine phosphatase activity • phosphatidylinositol phosphate phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • phosphatidylinositol-3-phosphatase activity • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Cellular component • cytoplasm • synaptic membrane • cytosol • endosome • early endosome membrane • membrane • vacuolar membrane • synaptic vesicle • dendritic spine • axon • dendrite • extracellular exosome • nucleus • postsynaptic density of dendrite • intracellular membrane-bounded organelle Biological process • negative regulation of endocytosis • phosphatidylinositol metabolic process • negative regulation of receptor catabolic process • myelin assembly • lipid metabolic process • negative regulation of receptor internalization • protein dephosphorylation • neuron development • protein tetramerization • negative regulation of excitatory postsynaptic potential • dendritic spine maintenance • phosphatidylinositol dephosphorylation • positive regulation of early endosome to late endosome transport • phosphatidylinositol biosynthetic process • peptidyl-tyrosine dephosphorylation • negative regulation of myelination • inositol phosphate dephosphorylation • dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8898	77116
Ensembl	ENSG00000087053	ENSMUSG00000031918
UniProt	Q13614	Q9Z2D1
RefSeq (mRNA)	NM_001243571 NM_016156 NM_201278 NM_201281	NM_023858
RefSeq (protein)	NP_001230500 NP_057240 NP_958435 NP_958438	NP_076347
Location (UCSC)	Chr 11: 95.83 – 95.93 Mb	Chr 9: 13.75 – 13.81 Mb
PubMed search

1LW3, 1M7R, 1ZSQ, 1ZVR

8898

77116

ENSG00000087053

ENSMUSG00000031918

Q13614

Q9Z2D1

NM_001243571
NM_016156
NM_201278
NM_201281

NM_023858

NP_001230500
NP_057240
NP_958435
NP_958438

NP_076347

Myotubularin-related protein 2 is a protein that in humans is encoded by the MTMR2 gene.

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