MT2 receptor

MTNR1B
Identifiers
Aliases	MTNR1B, FGQTL2, MEL-1B-R, MT2, Melatonin receptor 1B
External IDs	MGI: 2181726 HomoloGene: 4350 GeneCards: MTNR1B
Gene location (Human) Chr. Chromosome 11 (human) Band n/a Start 92,969,720 bp End 92,985,066 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band n/a Start 15,824,528 bp End 15,874,556 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • melatonin receptor activity • protein binding • G-protein coupled receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • plasma Biological process • G-protein coupled receptor signaling pathway • glucose homeostasis • regulation of insulin secretion • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • circadian rhythm • signal transduction • chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4544	244701
Ensembl	ENSG00000134640	ENSMUSG00000050901
UniProt	P49286	Q8CIQ6 Q3SXF8
RefSeq (mRNA)	NM_005959	NM_145712
RefSeq (protein)	NP_005950	NP_663758
Location (UCSC)	Chr 11: 92.97 – 92.99 Mb	Chr 11: 15.82 – 15.87 Mb
PubMed search

4544

244701

ENSG00000134640

ENSMUSG00000050901

P49286

Q8CIQ6
Q3SXF8

NM_005959

NM_145712

NP_005950

NP_663758

Melatonin receptor 1B, also known as MTNR1B, is a protein that in humans is encoded by the MTNR1B gene.

This gene encodes the MT₂protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain; however, this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. Besides the brain and retina this receptor is expressed on the bone forming cells where it regulates their function in depositing bone.

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