MSH2

MSH2

Protein MSH2 PDB 2o8b.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2O8B, 2O8C, 2O8D, 2O8E, 2O8F, 3THW, 3THX, 3THY, 3THZ

Identifiers

MSH2, mutS homolog 2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2

External IDs

OMIM: 609309 MGI: 101816 HomoloGene: 210 GeneCards: MSH2

Gene ontology
Molecular function	• DNA binding • nucleotide binding • protein homodimerization activity • mismatched DNA binding • dinucleotide insertion or deletion binding • ADP binding • centromeric DNA binding • oxidized purine DNA binding • single-stranded DNA binding • damaged DNA binding • ATPase activity • protein C-terminus binding • protein binding • single thymine insertion binding • four-way junction DNA binding • MutLalpha complex binding • enzyme binding • double-stranded DNA binding • dinucleotide repeat insertion binding • ATP binding • protein kinase binding • magnesium ion binding • single guanine insertion binding • guanine/thymine mispair binding
Cellular component	• MutSbeta complex • membrane • MutSalpha complex • nucleoplasm • mismatch repair complex • nucleus • nuclear chromosome, telomeric region
Biological process	• negative regulation of neuron apoptotic process • germ cell development • male gonad development • postreplication repair • determination of adult lifespan • in utero embryonic development • cellular response to DNA damage stimulus • oxidative phosphorylation • maintenance of DNA repeat elements • positive regulation of helicase activity • cell cycle arrest • somatic recombination of immunoglobulin gene segments • intrinsic apoptotic signaling pathway in response to DNA damage • negative regulation of DNA recombination • somatic recombination of immunoglobulin genes involved in immune response • mismatch repair • B cell differentiation • B cell mediated immunity • DNA repair • double-strand break repair • response to X-ray • response to UV-B • somatic hypermutation of immunoglobulin genes • intra-S DNA damage checkpoint • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • isotype switching • positive regulation of isotype switching to IgA isotypes • positive regulation of isotype switching to IgG isotypes
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE MSH2 209421 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


4436


17685


ENSG00000095002


ENSMUSG00000024151


P43246


P43247

RefSeq (mRNA)


NM_000251 NM_001258281


NM_008628

RefSeq (protein)


NP_000242 NP_001245210


NP_032654.1 NP_032654

Location (UCSC)

Chr 2: 47.4 – 47.56 Mb

Chr 17: 87.67 – 87.72 Mb

PubMed search

2O8B, 2O8C, 2O8D, 2O8E, 2O8F, 3THW, 3THX, 3THY, 3THZ

ENSG00000095002

ENSMUSG00000024151

NM_000251
NM_001258281

NP_000242
NP_001245210

NP_032654.1
NP_032654

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Wikipedia

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