MMP20

MMP20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JSD
Identifiers
Aliases	MMP20, AI2A2, MMP-20, matrix metallopeptidase 20
External IDs	MGI: 1353466 HomoloGene: 21001 GeneCards: MMP20
Gene ontology Molecular function • calcium ion binding • zinc ion binding • peptidase activity • metalloendopeptidase activity • protein binding • hydrolase activity • metallopeptidase activity • metal ion binding • serine-type endopeptidase activity Cellular component • extracellular matrix • proteinaceous extracellular matrix • extracellular region • extracellular space Biological process • collagen catabolic process • protein catabolic process • regulation of enamel mineralization • proteolysis • amelogenesis • extracellular matrix disassembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9313	30800
Ensembl	ENSG00000137674	ENSMUSG00000018620
UniProt	O60882	P57748
RefSeq (mRNA)	NM_004771	NM_013903
RefSeq (protein)	NP_004762	NP_038931.1 NP_038931
Location (UCSC)	Chr 11: 102.58 – 102.63 Mb	Chr 9: 7.63 – 7.67 Mb
PubMed search

2JSD

9313

30800

ENSG00000137674

ENSMUSG00000018620

O60882

P57748

NM_004771

NM_013903

NP_004762

NP_038931.1
NP_038931

Matrix metalloproteinase-20 (MMP-20) also known as enamel metalloproteinase or enamelysin is an enzyme that in humans is encoded by the MMP20 gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.

MMP-20, also known as enamelysin, appears to be the only MMP that is tooth-specific and it is expressed by cells of different developmental origin (i.e. epithelial ameloblasts and mesenchymal odontoblasts).

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