MMP14

MMP14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BQQ, 1BUV, 2MQS, 3C7X, 3MA2, 4P3C, 4P3D, 4QXU, 3X23
Identifiers
Aliases	MMP14, MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS, matrix metallopeptidase 14
External IDs	MGI: 101900 HomoloGene: 21040 GeneCards: MMP14
Gene ontology Molecular function • zinc ion binding • metal ion binding • integrin binding • peptidase activity • protein binding • metalloendopeptidase activity • peptidase activator activity • metallopeptidase activity • hydrolase activity • serine-type endopeptidase activity • metalloaminopeptidase activity Cellular component • cytoplasm • integral component of membrane • membrane • focal adhesion • extracellular matrix • melanosome • plasma membrane • integral component of plasma membrane • macropinosome • Golgi lumen • cytoplasmic vesicle • extracellular space • nucleus • cytosol • intermediate filament cytoskeleton Biological process • positive regulation of myotube differentiation • male gonad development • response to hypoxia • endodermal cell differentiation • response to organic cyclic compound • ossification • lung development • astrocyte cell migration • positive regulation of cell migration • positive regulation of B cell differentiation • zymogen activation • response to mechanical stimulus • extracellular matrix disassembly • endochondral ossification • response to oxidative stress • craniofacial suture morphogenesis • proteolysis • positive regulation of peptidase activity • response to estrogen • positive regulation of cell growth • endothelial cell proliferation • chondrocyte proliferation • angiogenesis • collagen catabolic process • ovarian follicle development • embryonic cranial skeleton morphogenesis • response to hormone • tissue remodeling • bone development • branching morphogenesis of an epithelial tube • negative regulation of focal adhesion assembly • cell migration • negative regulation of Notch signaling pathway • protein processing • cell motility • positive regulation of macrophage migration • response to odorant Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4323	17387
Ensembl	ENSG00000157227	ENSMUSG00000000957
UniProt	P50281	P53690
RefSeq (mRNA)	NM_004995	NM_008608
RefSeq (protein)	NP_004986	NP_032634
Location (UCSC)	Chr 14: 22.84 – 22.85 Mb	Chr 14: 54.43 – 54.44 Mb
PubMed search

1BQQ, 1BUV, 2MQS, 3C7X, 3MA2, 4P3C, 4P3D, 4QXU, 3X23

4323

17387

ENSG00000157227

ENSMUSG00000000957

P50281

P53690

NM_004995

NM_008608

NP_004986

NP_032634

Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive pro-proteins which are activated when cleaved by extracellular proteinases.

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Wikipedia