MKK7

MAP2K7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M
Identifiers
Aliases	MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 7
External IDs	MGI: 1346871 HomoloGene: 56548 GeneCards: MAP2K7
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 7,903,843 bp End 7,914,478 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A1.1 Start 4,238,740 bp End 4,247,897 bp
Gene ontology Molecular function • metal ion binding • nucleotide binding • protein tyrosine kinase activity • protein kinase binding • protein kinase activity • magnesium ion binding • transferase activity • kinase activity • ATP binding • enzyme binding • protein phosphatase binding • protein binding • MAP kinase kinase activity • protein serine/threonine kinase activity Cellular component • nucleus • cytoplasm • cytosol Biological process • response to UV • signal transduction • positive regulation of telomerase activity • positive regulation of telomere maintenance via telomerase • Fc-epsilon receptor signaling pathway • positive regulation of telomere capping • apoptotic process • response to osmotic stress • peptidyl-tyrosine phosphorylation • response to tumor necrosis factor • protein phosphorylation • response to heat • phosphorylation • stress-activated MAPK cascade • JNK cascade • proteolysis in other organism • activation of JUN kinase activity • regulation of mitotic cell cycle • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5609	26400
Ensembl	ENSG00000076984	ENSMUSG00000002948
UniProt	O14733	Q8CE90
RefSeq (mRNA)	NM_001297555 NM_001297556 NM_145185	NM_001042557 NM_001164172 NM_001291777 NM_001291778 NM_001291783 NM_011944
RefSeq (protein)	NP_001284484 NP_001284485 NP_660186	NP_001036022 NP_001157644 NP_001278706 NP_001278707 NP_001278712 NP_036074
Location (UCSC)	Chr 19: 7.9 – 7.91 Mb	Chr 19: 4.24 – 4.25 Mb
PubMed search

2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M

5609

26400

ENSG00000076984

ENSMUSG00000002948

O14733

Q8CE90

NM_001297555
NM_001297556
NM_145185

NM_011944

NP_001284484
NP_001284485
NP_660186

NP_036074

Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene. This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different isoforms with three possible N-termini (α, β, and γ isoforms) and two possible C-termini (1 and 2 isoforms).

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