MKK4

MAP2K4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3ALN, 3ALO, 3VUT

Identifiers

Aliases

MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4

External IDs

MGI: 1346869 HomoloGene: 48159 GeneCards: MAP2K4

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	No data available	Start	12,020,824 bp
Band	No data available	End	12,143,830 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	No data available	Start	65,688,243 bp
Band	No data available	End	65,788,297 bp

Gene ontology
Molecular function	• transferase activity • protein kinase activity • nucleotide binding • kinase activity • protein binding • protein tyrosine kinase activity • ATP binding • mitogen-activated protein kinase kinase kinase binding • MAP kinase kinase activity • JUN kinase kinase activity • protein serine/threonine kinase activity
Cellular component	• cytoplasm • nucleus • dendrite cytoplasm • cytosol • perikaryon • axon
Biological process	• phosphorylation • MAPK cascade • Fc-epsilon receptor signaling pathway • protein phosphorylation • cellular response to mechanical stimulus • response to wounding • peptidyl-tyrosine phosphorylation • signal transduction • negative regulation of motor neuron apoptotic process • apoptotic process • cell growth involved in cardiac muscle cell development • cellular response to sorbitol • positive regulation of smooth muscle cell apoptotic process • JNK cascade • proteolysis in other organism • positive regulation of protein phosphorylation • positive regulation of neuron apoptotic process • positive regulation of DNA replication • activation of JUN kinase activity • positive regulation of apoptotic process • positive regulation of nitric-oxide synthase biosynthetic process • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6416


26398

Ensembl


ENSG00000065559


ENSMUSG00000033352

UniProt


P45985


P47809

RefSeq (mRNA)


NM_001281435 NM_003010


NM_009157 NM_001316367 NM_001316368 NM_001316369

RefSeq (protein)


NP_001268364 NP_003001


NP_001303296 NP_001303297 NP_001303298 NP_033183

Location (UCSC)

Chr 17: 12.02 – 12.14 Mb

Chr 17: 65.69 – 65.79 Mb

PubMed search

3ALN, 3ALO, 3VUT

NM_001281435
NM_003010

NM_009157
NM_001316367
NM_001316368
NM_001316369

NP_001268364
NP_003001

NP_001303296
NP_001303297
NP_001303298
NP_033183

...
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