MKK3

MAP2K3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LEZ
Identifiers
Aliases	MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, mitogen-activated protein kinase kinase 3
External IDs	MGI: 1346868 HomoloGene: 56430 GeneCards: MAP2K3
Gene ontology Molecular function • ATP binding • protein tyrosine kinase activity • protein kinase activity • protein binding • kinase activity • nucleotide binding • transferase activity • MAP kinase kinase activity • protein kinase binding • protein serine/threonine kinase activity Cellular component • nucleoplasm • cytosol • membrane • cytoplasm Biological process • MAPK cascade • protein phosphorylation • positive regulation of transcription, DNA-templated • peptidyl-tyrosine phosphorylation • phosphorylation • signal transduction • positive regulation of protein kinase activity • proteolysis in other organism • activation of MAPK activity • inflammatory response • regulation of cytokine biosynthetic process • cardiac muscle contraction • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5606	26397
Ensembl	ENSG00000034152	ENSMUSG00000018932
UniProt	P46734	O09110
RefSeq (mRNA)	NM_002756 NM_145109 NM_145110 NM_001316332	NM_008928
RefSeq (protein)	NP_001303261 NP_002747 NP_659731	NP_032954.1 NP_032954
Location (UCSC)	Chr 17: 21.28 – 21.32 Mb	Chr 11: 60.93 – 60.95 Mb
PubMed search

1LEZ

5606

26397

ENSG00000034152

ENSMUSG00000018932

P46734

O09110

NM_002756
NM_145109
NM_145110
NM_001316332

NM_008928

NP_001303261
NP_002747
NP_659731

NP_032954.1
NP_032954

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

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