MGluR3

GRM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SM9, 4XAR, 5CNK, 5CNM
Identifiers
Aliases	GRM3, GLUR3, GPRC1C, MGLUR3, mGlu3, glutamate metabotropic receptor 3
External IDs	MGI: 1351340 HomoloGene: 651 GeneCards: GRM3
Targeted by Drug
DCG-IV, eglumetad, LY379268, isospaglumic acid, Ro4491533
Gene ontology Molecular function • glutamate receptor activity • group II metabotropic glutamate receptor activity • calcium channel regulator activity • signal transducer activity • G-protein coupled receptor activity Cellular component • integral component of membrane • axon • neuron projection • dendritic spine • postsynaptic membrane • integral component of plasma membrane • postsynaptic density • membrane • plasma membrane • presynaptic membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • signal transduction • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • G-protein coupled glutamate receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2913	108069
Ensembl	ENSG00000198822	ENSMUSG00000003974
UniProt	Q14832	Q9QYS2
RefSeq (mRNA)	NM_000840	NM_181850
RefSeq (protein)	NP_000831	NP_862898.1 NP_862898
Location (UCSC)	Chr 7: 86.64 – 86.86 Mb	Chr 5: 9.49 – 9.73 Mb
PubMed search

3SM9, 4XAR, 5CNK, 5CNM

2913

108069

ENSG00000198822

ENSMUSG00000003974

Q14832

Q9QYS2

NM_000840

NM_181850

NP_000831

NP_862898.1
NP_862898

Metabotropic glutamate receptor 3 is a protein that in humans is encoded by the GRM3 gene.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

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Wikipedia