MGST2

MGST2
Identifiers
Aliases	MGST2, GST2, MGST-II, microsomal glutathione S-transferase 2
External IDs	MGI: 2448481 HomoloGene: 1811 GeneCards: MGST2
Gene ontology Molecular function • enzyme activator activity • glutathione peroxidase activity • leukotriene-C4 synthase activity • transferase activity • glutathione transferase activity • protein binding Cellular component • integral component of membrane • intracellular membrane-bounded organelle • organelle membrane • membrane • plasma membrane • cytoplasm • endoplasmic reticulum membrane • endoplasmic reticulum • nuclear envelope Biological process • glutathione derivative biosynthetic process • leukotriene metabolic process • leukotriene biosynthetic process • glutathione biosynthetic process • response to lipopolysaccharide • positive regulation of catalytic activity • response to organonitrogen compound • xenobiotic metabolic process • cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4258	211666
Ensembl	ENSG00000085871	ENSMUSG00000074604
UniProt	Q99735	n/a
RefSeq (mRNA)	NM_001204366 NM_001204367 NM_001204368 NM_002413	NM_174995 NM_001310482
RefSeq (protein)	NP_001191295 NP_001191296 NP_001191297 NP_002404	n/a
Location (UCSC)	Chr 4: 139.67 – 139.74 Mb	Chr 3: 51.66 – 51.68 Mb
PubMed search

4258

211666

ENSG00000085871

ENSMUSG00000074604

Q99735

n/a

NM_001204366
NM_001204367
NM_001204368
NM_002413

NM_174995
NM_001310482

NP_001191295
NP_001191296
NP_001191297
NP_002404

n/a

Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.

...
Wikipedia