METTL3

METTL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IL0, 5IL2, 5IL1, 5K7M, 5K7U, 5K7W
Identifiers
Aliases	METTL3, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hMETTL3
External IDs	MGI: 1927165 HomoloGene: 10501 GeneCards: METTL3
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 21,498,133 bp End 21,511,375 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C2 Start 52,294,668 bp End 52,305,128 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • RNA binding • RNA methyltransferase activity • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity • mRNA binding • S-adenosyl-L-methionine binding • protein heterodimerization activity • protein binding Cellular component • RNA N6-methyladenosine methyltransferase complex • nucleoplasm • nuclear speck • nucleus • cytoplasm Biological process • rhythmic process • mRNA processing • positive regulation of cap-independent translational initiation • stem cell population maintenance • primary miRNA methylation • methylation • mRNA methylation • mRNA destabilization • circadian rhythm • primary miRNA processing • nucleobase-containing compound metabolic process • adenosine to inosine editing • RNA methylation • RNA metabolic process • mRNA splicing, via spliceosome • mRNA catabolic process • cellular response to DNA damage stimulus • spermatogenesis • forebrain radial glial cell differentiation • cellular response to UV • gliogenesis • regulation of T cell differentiation • negative regulation of Notch signaling pathway • regulation of meiotic cell cycle • endothelial to hematopoietic transition • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56339	56335
Ensembl	ENSG00000165819	ENSMUSG00000022160
UniProt	Q86U44	Q8C3P7
RefSeq (mRNA)	NM_019852	NM_019721
RefSeq (protein)	NP_062826	NP_062695
Location (UCSC)	Chr 14: 21.5 – 21.51 Mb	Chr 14: 52.29 – 52.31 Mb
PubMed search

5IL0, 5IL2, 5IL1, 5K7M, 5K7U, 5K7W

56339

56335

ENSG00000165819

ENSMUSG00000022160

Q86U44

Q8C3P7

NM_019852

NM_019721

NP_062826

NP_062695

N6-adenosine-methyltransferase 70 kDa subunit is an enzyme that in humans is encoded by the METTL3 gene.

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.

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Wikipedia