MERTK

MERTK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DBJ, 2P0C, 3BPR, 3BRB, 3TCP, 4M3Q, 4MH7, 4MHA
Identifiers
Aliases	MERTK, MER, RP38, c-mer, Tyro12, c-Eyk, MER proto-oncogene, tyrosine kinase
External IDs	MGI: 96965 HomoloGene: 4626 GeneCards: MERTK
Genetically Related Diseases
hepatitis C, multiple sclerosis
Gene ontology Molecular function • ATP binding • protein tyrosine kinase activity • protein kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • kinase activity • nucleotide binding • transferase activity Cellular component • integral component of membrane • photoreceptor outer segment • rhabdomere • membrane • integral component of plasma membrane • plasma membrane • cytoplasm • extracellular space Biological process • spermatogenesis • vagina development • protein kinase B signaling • natural killer cell differentiation • cell surface receptor signaling pathway • protein phosphorylation • platelet activation • cell-cell signaling • positive regulation of phagocytosis • apoptotic cell clearance • substrate adhesion-dependent cell spreading • leukocyte migration • negative regulation of lymphocyte activation • phosphorylation • retina development in camera-type eye • negative regulation of leukocyte apoptotic process • phagocytosis • secretion by cell • peptidyl-tyrosine phosphorylation • negative regulation of cytokine production • neutrophil clearance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10461	17289
Ensembl	ENSG00000153208	ENSMUSG00000014361
UniProt	Q12866	Q60805
RefSeq (mRNA)	NM_006343	NM_008587
RefSeq (protein)	NP_006334	NP_032613.1 NP_032613
Location (UCSC)	Chr 2: 111.9 – 112.03 Mb	Chr 2: 128.7 – 128.8 Mb
PubMed search

2DBJ, 2P0C, 3BPR, 3BRB, 3TCP, 4M3Q, 4MH7, 4MHA

10461

17289

ENSG00000153208

ENSMUSG00000014361

Q12866

Q60805

NM_006343

NM_008587

NP_006334

NP_032613.1
NP_032613

Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

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