MEN1

MEN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9, 5DDA, 5DDE, 5DDB, 5DDD, 5DDC, 5DB0, 5DB3, 5DB1, 5DB2
Identifiers
Aliases	MEN1, MEAI, SCG2, menin 1
External IDs	OMIM: 613733 MGI: 1316736 HomoloGene: 7418 GeneCards: MEN1
Gene ontology Molecular function • DNA binding • protein binding, bridging • R-SMAD binding • protein N-terminus binding • chromatin binding • histone-lysine N-methyltransferase activity • protein binding • four-way junction DNA binding • Y-form DNA binding • transcription regulatory region DNA binding • double-stranded DNA binding Cellular component • cytoplasm • cytosol • nuclear matrix • nucleoplasm • protein complex • nuclear chromatin • chromatin • cleavage furrow • nuclear chromosome, telomeric region • nucleus • histone methyltransferase complex Biological process • negative regulation of cell-substrate adhesion • negative regulation of protein phosphorylation • positive regulation of transforming growth factor beta receptor signaling pathway • regulation of transcription, DNA-templated • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of telomerase activity • negative regulation of cell cycle • regulation of activin receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of osteoblast differentiation • negative regulation of cell cycle G1/S phase transition • MAPK cascade • cellular response to DNA damage stimulus • negative regulation of JNK cascade • brain development • cellular response to peptide hormone stimulus • decidualization • negative regulation of epithelial cell proliferation • mitotic cell cycle • osteoblast development • positive regulation of protein binding • negative regulation of transcription, DNA-templated • response to gamma radiation • response to UV • type B pancreatic cell differentiation • DNA repair • regulation of type B pancreatic cell proliferation • cellular response to glucose stimulus • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • response to transforming growth factor beta • histone lysine methylation • beta-catenin-TCF complex assembly • transcription, DNA-templated • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4221	17283
Ensembl	ENSG00000133895	n/a
UniProt	O00255	O88559
RefSeq (mRNA)	NM_000244 NM_130799 NM_130800 NM_130801 NM_130802 NM_130803 NM_130804	NM_001168488 NM_001168489 NM_001168490 NM_008583
RefSeq (protein)	NP_000235 NP_570711 NP_570712 NP_570713 NP_570714 NP_570715 NP_570716	NP_001161960.1 NP_001161961.1 NP_001161962.1 NP_032609.1 NP_001161960 NP_001161961 NP_001161962 NP_032609
Location (UCSC)	Chr 11: 64.8 – 64.81 Mb	Chr 19: 6.33 – 6.34 Mb
PubMed search

3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9, 5DDA, 5DDE, 5DDB, 5DDD, 5DDC, 5DB0, 5DB3, 5DB1, 5DB2

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