MEK1

MAP2K1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S9J, 2P55, 3DV3, 3DY7, 3E8N, 3EQB, 3EQC, 3EQD, 3EQF, 3EQG, 3EQH, 3EQI, 3MBL, 3ORN, 3OS3, 3PP1, 3SLS, 3V01, 3V04, 3VVH, 3W8Q, 3WIG, 3ZLS, 3ZLW, 3ZLX, 3ZLY, 3ZM4, 4AN2, 4AN3, 4AN9, 4ANB, 4ARK, 4LMN, 4MNE, 4U7Z, 4U80, 4U81, 5BX0
Identifiers
Aliases	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1, mitogen-activated protein kinase kinase 1
External IDs	MGI: 1346866 HomoloGene: 2063 GeneCards: MAP2K1
Gene ontology Molecular function • signal transducer, downstream of receptor, with protein tyrosine phosphatase activity • protein N-terminus binding • kinase activity • protein C-terminus binding • ATP binding • protein kinase activity • transferase activity • protein serine/threonine kinase activator activity • protein binding • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • nucleotide binding • MAP kinase kinase activity • protein serine/threonine kinase activity Cellular component • membrane • focal adhesion • microtubule organizing center • mitochondrion • cytoskeleton • nucleus • endoplasmic reticulum • extracellular exosome • late endosome • Golgi apparatus • early endosome • cytoplasm • cytosol • plasma membrane Biological process • regulation of protein phosphorylation • movement of cell or subcellular component • positive regulation of axonogenesis • positive regulation of protein serine/threonine kinase activity • protein phosphorylation • cellular senescence • face development • cerebellar cortex formation • negative regulation of cell proliferation • thymus development • cell motility • ERK1 and ERK2 cascade • negative regulation of gene expression • heart development • positive regulation of cell differentiation • regulation of stress-activated MAPK cascade • phosphorylation • epithelial cell proliferation involved in lung morphogenesis • chemotaxis • thyroid gland development • activation of MAPK activity • neuron differentiation • trachea formation • regulation of axon regeneration • lung morphogenesis • regulation of early endosome to late endosome transport • labyrinthine layer development • placenta blood vessel development • keratinocyte differentiation • MAPK cascade • positive regulation of gene expression • cell cycle arrest • Bergmann glial cell differentiation • peptidyl-tyrosine phosphorylation • regulation of Golgi inheritance • signal transduction • positive regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of ERK1 and ERK2 cascade • proteolysis in other organism • positive regulation of transcription, DNA-templated • regulation of mitotic cell cycle • regulation of apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5604	26395
Ensembl	ENSG00000169032	ENSMUSG00000004936
UniProt	Q02750	P31938
RefSeq (mRNA)	NM_002755	NM_008927
RefSeq (protein)	NP_002746	NP_032953
Location (UCSC)	Chr 15: 66.39 – 66.49 Mb	Chr 9: 64.19 – 64.25 Mb
PubMed search

1S9J, 2P55, 3DV3, 3DY7, 3E8N, 3EQB, 3EQC, 3EQD, 3EQF, 3EQG, 3EQH, 3EQI, 3MBL, 3ORN, 3OS3, 3PP1, 3SLS, 3V01, 3V04, 3VVH, 3W8Q, 3WIG, 3ZLS, 3ZLW, 3ZLX, 3ZLY, 3ZM4, 4AN2, 4AN3, 4AN9, 4ANB, 4ARK, 4LMN, 4MNE, 4U7Z, 4U80, 4U81, 5BX0

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