MEGF10

MEGF10
Identifiers
Aliases	MEGF10, EMARDD, multiple EGF like domains 10
External IDs	MGI: 2685177 HomoloGene: 23771 GeneCards: MEGF10
Gene ontology Molecular function • complement component C1q binding • scavenger receptor activity • Notch binding Cellular component • integral component of membrane • cell projection • basolateral plasma membrane • membrane • phagocytic cup • plasma membrane Biological process • skeletal muscle satellite cell differentiation • regulation of skeletal muscle tissue development • homotypic cell-cell adhesion • recognition of apoptotic cell • muscle organ development • skeletal muscle satellite cell activation • cell adhesion • muscle cell development • regulation of muscle cell differentiation • skeletal muscle satellite cell proliferation • phagocytosis • receptor-mediated endocytosis • muscle cell proliferation • engulfment of apoptotic cell • myoblast migration • apoptotic process involved in development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84466	70417
Ensembl	ENSG00000145794	ENSMUSG00000024593
UniProt	Q96KG7	Q6DIB5
RefSeq (mRNA)	NM_001256545 NM_001308119 NM_001308121 NM_032446	NM_001001979
RefSeq (protein)	NP_001243474 NP_001295048 NP_001295050 NP_115822	NP_001001979
Location (UCSC)	Chr 5: 127.29 – 127.47 Mb	Chr 18: 57.13 – 57.3 Mb
PubMed search

84466

70417

ENSG00000145794

ENSMUSG00000024593

Q96KG7

Q6DIB5

NM_001256545
NM_001308119
NM_001308121
NM_032446

NM_001001979

NP_001243474
NP_001295048
NP_001295050
NP_115822

NP_001001979

Multiple EGF-like-domains 10 is a protein that in humans is encoded by the MEGF10 gene.

MEGF10 is a regulator of satellite cell myogenesis and interacts with Notch1 in myoblasts. It has been shown to be the cause of early-onset myopathy, areflexia, respiratory distress and dysphagia.

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Wikipedia