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MEFV

MEFV
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MEFV, FMF, MEF, TRIM20, Mediterranean fever, pyrin innate immunity regulator
External IDs OMIM: 608107 MGI: 1859396 HomoloGene: 32441 GeneCards: MEFV
RNA expression pattern
PBB GE MEFV 208262 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001198536
NM_000243

NM_001161790
NM_001161791
NM_019453

RefSeq (protein)

NP_000234
NP_001185465

NP_001155262
NP_001155263
NP_062326

Location (UCSC) Chr 16: 3.24 – 3.26 Mb Chr 16: 3.71 – 3.72 Mb
PubMed search

2WL1, 2MPC, 4CG4

NM_001198536
NM_000243

NM_001161790
NM_001161791
NM_019453

NP_000234
NP_001185465

NP_001155262
NP_001155263
NP_062326

MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells (neutrophils, eosinophils and monocytes) that play a role in inflammation and in fighting infection. Inside these white blood cells, pyrin is found with the cytoskeleton, the structural framework that helps to define the shape, size, and movement of a cell. Pyrin's protein structure also allows it to interact with other molecules involved in fighting infection and in the inflammatory response.


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Wikipedia

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