MEFV

MEFV
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WL1, 2MPC, 4CG4
Identifiers
Aliases	MEFV, FMF, MEF, TRIM20, Mediterranean fever, pyrin innate immunity regulator
External IDs	OMIM: 608107 MGI: 1859396 HomoloGene: 32441 GeneCards: MEFV
Gene ontology Molecular function • zinc ion binding • metal ion binding • protein binding • actin binding • identical protein binding Cellular component • cytoplasm • cytosol • cell projection • ruffle • intracellular • microtubule associated complex • autophagosome • microtubule • cytoskeleton • cytoplasmic vesicle • nucleus • lamellipodium Biological process • positive regulation of cysteine-type endopeptidase activity • negative regulation of interleukin-1 beta production • response to interferon-gamma • positive regulation of autophagy • negative regulation of macrophage inflammatory protein 1 alpha production • immune system process • negative regulation of NLRP3 inflammasome complex assembly • inflammatory response • negative regulation of inflammatory response • negative regulation of cytokine production involved in inflammatory response • negative regulation of interleukin-12 production • innate immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4210	54483
Ensembl	ENSG00000103313	ENSMUSG00000022534
UniProt	O15553	Q9JJ26
RefSeq (mRNA)	NM_001198536 NM_000243	NM_001161790 NM_001161791 NM_019453
RefSeq (protein)	NP_000234 NP_001185465	NP_001155262 NP_001155263 NP_062326
Location (UCSC)	Chr 16: 3.24 – 3.26 Mb	Chr 16: 3.71 – 3.72 Mb
PubMed search

2WL1, 2MPC, 4CG4

4210

54483

ENSG00000103313

ENSMUSG00000022534

O15553

Q9JJ26

NM_001198536
NM_000243

NM_001161790
NM_001161791
NM_019453

NP_000234
NP_001185465

NP_001155262
NP_001155263
NP_062326

MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells (neutrophils, eosinophils and monocytes) that play a role in inflammation and in fighting infection. Inside these white blood cells, pyrin is found with the cytoskeleton, the structural framework that helps to define the shape, size, and movement of a cell. Pyrin's protein structure also allows it to interact with other molecules involved in fighting infection and in the inflammatory response.

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Wikipedia