MED15

MED15
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2GUT
Identifiers
Aliases	MED15, ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7, mediator complex subunit 15
External IDs	GeneCards: MED15
Gene ontology Molecular function • RNA polymerase II transcription cofactor activity • protein binding Cellular component • cytoplasm • mediator complex • membrane • nucleus • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51586	n/a
Ensembl	ENSG00000099917	n/a
UniProt	Q96RN5	n/a
RefSeq (mRNA)	NM_001003891 NM_001293234 NM_001293235 NM_001293236 NM_001293237 NM_015889	n/a
RefSeq (protein)	NP_001003891 NP_001280163 NP_001280164 NP_001280165 NP_001280166 NP_056973	n/a
Location (UCSC)	Chr 22: 20.5 – 20.59 Mb	n/a
PubMed search		n/a

2GUT

51586

n/a

ENSG00000099917

n/a

Q96RN5

n/a

NM_015889

n/a

NP_056973

n/a

Mediator of RNA polymerase II transcription subunit 15, also known as Gal11,Spt13 in yeast and PCQAP, ARC105, or TIG-1 in humans is a protein encoded by the MED15 gene.

MED15 is a general transcriptional cofactor of the mediator complex involved in RNA polymerase II dependent transcription, originally called Gal11 and Spt13 and found in yeast as an essential factor for Gal4 dependent transactivation by T.Fukasawa and F.Winston labs. Transcription factors Gcn4, Pho4, Msn2, Ino2, members of the Gal4 family - Gal4, Oaf1, Pdr1, and viral VP16 have been reported to interact with yeast MED15.

Most of these transcription factors share the same transactivation domain, 9aaTAD, which directly interacts with KIX domain of the MED15.

Furthermore, human MED15 cooperates in mediator complex (previously known as PC2, ARC, or DRIP) with transcription factors like VP16 and SREBP. Human SREBP regulates sterol responsive gene expression, and this regulatory action is conserved in the genetic model organism C. elegans, a roundworm (homologues MDT-15 and SBP-1). Also in C. elegans, MDT-15 is essential for the response to several stresses (fasting, heavy metal, toxin, and oxidative stress); at least in part the fasting response is conferred by interactions of MDT-15 with nuclear receptors, including NHR-49.

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