MDR1

ABCB1
Identifiers
Aliases	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1
External IDs	MGI: 97570 HomoloGene: 55496 GeneCards: ABCB1
Gene ontology Molecular function • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • transporter activity • ATPase activity • protein binding • hydrolase activity • ATP binding • xenobiotic-transporting ATPase activity • phosphatidylethanolamine-translocating ATPase activity • phosphatidylcholine-translocating ATPase activity • ceramide-translocating ATPase activity Cellular component • integral component of membrane • membrane • plasma membrane • cell surface • extracellular exosome • apical plasma membrane Biological process • stem cell proliferation • xenobiotic transport • G2/M transition of mitotic cell cycle • transmembrane transport • transport • response to drug • phospholipid translocation • drug transmembrane transport • ceramide translocation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5243	18671
Ensembl	ENSG00000085563	ENSMUSG00000040584
UniProt	P08183	P21447
RefSeq (mRNA)	NM_000927	NM_011076
RefSeq (protein)	NP_000918 NP_001335873 NP_001335874 NP_001335875	NP_035206.2 NP_035206
Location (UCSC)	Chr 7: 87.5 – 87.71 Mb	Chr 5: 8.66 – 8.75 Mb
PubMed search

ABCB1 at EBI Gene Expression Atlas
ABCB1 is differentially expressed in 97 experiments [93 up/106 dn]: 26 organism parts: kidney [2 up/0 dn], bone marrow [0 up/2 dn], ...; 29 disease states: normal [10 up/3 dn], glioblastoma [0 up/2 dn], ...; 30 cell types, 22 cell lines, 11 compound treatments and 16 other conditions.
Factor Value	Factor	Up/Down
Legend: - number of studies the gene is up/down in
Normal	Disease state	10/3
None	Compound treatment	3/0
Stromal cell	Cell type	1/2
Kidney	Cell type	2/0
MDA-MB-231	Cell line	0/2
Glioblastoma	Disease state	0/2
Epithelial cell	Cell type	0/2
HeLa	Cell line	0/2
Primary	Disease staging	2/0
Bone marrow	Organism part	0/2
ABCB1 expression data in ATLAS

5243

18671

ENSG00000085563

ENSMUSG00000040584

P08183

P21447

NM_000927

NM_011076

NP_000918
NP_001335873
NP_001335874
NP_001335875

NP_035206.2
NP_035206

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances.

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