MDM2

MDM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS, 3G03, 3IUX, 3IWY, 3JZK, 3JZR, 3JZS, 3LBK, 3LBL, 3LNJ, 3LNZ, 3MQS, 3TJ2, 3TPX, 3TU1, 3V3B, 3VBG, 3VZV, 3W69, 4DIJ, 4ERE, 4ERF, 4HBM, 4HFZ, 4HG7, 4JV7, 4JV9, 4JVE, 4JVR, 4JWR, 4MDN, 4MDQ, 4OAS, 4OBA, 4OCC, 4ODE, 4ODF, 4OGN, 4OGT, 4OGV, 4OQ3, 4QO4, 4QOC, 4UMN, 4WT2, 4XXB, 4ZYC, 4ZYF, 4ZYI, 4UE1, 4UD7, 5AFG, 5HMI, 5HMK, 5HMH, 5C5A
Identifiers
Aliases	MDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene
External IDs	MGI: 96952 HomoloGene: 1793 GeneCards: MDM2
Gene ontology Molecular function • scaffold protein binding • peroxisome proliferator activated receptor binding • protein binding • zinc ion binding • enzyme binding • metal ion binding • identical protein binding • ubiquitin protein ligase binding • p53 binding • SUMO transferase activity • ubiquitin protein ligase activity • ubiquitin-protein transferase activity • transferase activity • ligase activity Cellular component • cytosol • nucleolus • endocytic vesicle membrane • plasma membrane • synapse • nuclear body • protein complex • cytoplasm • nucleus • nucleoplasm Biological process • negative regulation of signal transduction by p53 class mediator • endocardial cushion morphogenesis • cellular response to UV-C • atrial septum development • regulation of heart rate • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • protein destabilization • positive regulation of gene expression • blood vessel development • positive regulation of cell proliferation • negative regulation of DNA damage response, signal transduction by p53 class mediator • response to ether • blood vessel remodeling • cellular response to hypoxia • heart valve development • cellular response to estrogen stimulus • negative regulation of apoptotic process • cellular response to organic substance • cellular response to hydrogen peroxide • response to cocaine • cardiac septum morphogenesis • negative regulation of transcription from RNA polymerase II promoter • peptidyl-lysine modification • response to drug • positive regulation of cell cycle • negative regulation of transcription, DNA-templated • ventricular septum development • positive regulation of protein export from nucleus • response to steroid hormone • cellular response to growth factor stimulus • regulation of protein catabolic process • cellular response to antibiotic • negative regulation of gene expression • positive regulation of mitotic cell cycle • heart development • cellular response to alkaloid • protein complex assembly • cellular response to vitamin B1 • response to magnesium ion • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • cellular response to peptide hormone stimulus • cellular response to organic cyclic compound • viral process • response to iron ion • regulation of gene expression • response to antibiotic • traversing start control point of mitotic cell cycle • negative regulation of cell cycle arrest • protein ubiquitination • negative regulation of protein processing • establishment of protein localization • response to toxic substance • response to morphine • atrioventricular valve morphogenesis • protein localization to nucleus • regulation of signal transduction by p53 class mediator • positive regulation of vascular smooth muscle cell proliferation • response to water-immersion restraint stress • negative regulation of neuron projection development • positive regulation of vascular associated smooth muscle cell migration • protein deubiquitination • protein sumoylation • transcription factor catabolic process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • protein autoubiquitination • response to formaldehyde Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4193	17246
Ensembl	ENSG00000135679	ENSMUSG00000020184
UniProt	Q00987	P23804
RefSeq (mRNA)	NM_001145336 NM_001145337 NM_001145339 NM_001145340 NM_001278462 NM_002392 NM_006878 NM_006879 NM_006880 NM_006881 NM_006882 NM_032739	NM_001288586 NM_010786
RefSeq (protein)	NP_001138809 NP_001138811 NP_001138812 NP_001265391 NP_002383	NP_001275515.1 NP_034916.1 NP_001275515 NP_034916
Location (UCSC)	Chr 12: 68.81 – 68.85 Mb	Chr 10: 117.69 – 117.71 Mb
PubMed search

1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS, 3G03, 3IUX, 3IWY, 3JZK, 3JZR, 3JZS, 3LBK, 3LBL, 3LNJ, 3LNZ, 3MQS, 3TJ2, 3TPX, 3TU1, 3V3B, 3VBG, 3VZV, 3W69, 4DIJ, 4ERE, 4ERF, 4HBM, 4HFZ, 4HG7, 4JV7, 4JV9, 4JVE, 4JVR, 4JWR, 4MDN, 4MDQ, 4OAS, 4OBA, 4OCC, 4ODE, 4ODF, 4OGN, 4OGT, 4OGV, 4OQ3, 4QO4, 4QOC, 4UMN, 4WT2, 4XXB, 4ZYC, 4ZYF, 4ZYI, 4UE1, 4UD7, 5AFG, 5HMI, 5HMK, 5HMH, 5C5A

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