MDA5

IFIH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RQB, 3B6E, 3GA3, 4GL2
Identifiers
Aliases	IFIH1, AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1, interferon induced with helicase C domain 1
External IDs	MGI: 1918836 HomoloGene: 32535 GeneCards: IFIH1
Genetically Related Diseases
type 1 diabetes mellitus
Gene ontology Molecular function • DNA binding • nucleotide binding • helicase activity • zinc ion binding • metal ion binding • protein binding • single-stranded RNA binding • RNA binding • double-stranded RNA binding • ribonucleoprotein complex binding • hydrolase activity • ATP binding • identical protein binding Cellular component • cytoplasm • cytosol • nucleus Biological process • positive regulation of interferon-alpha production • MDA-5 signaling pathway • immune system process • response to virus • protein sumoylation • cytoplasmic pattern recognition receptor signaling pathway in response to virus • defense response to virus • negative regulation of type I interferon production • detection of virus • viral process • innate immune response • regulation of type III interferon production • positive regulation of interferon-beta production • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64135	71586
Ensembl	ENSG00000115267	ENSMUSG00000026896
UniProt	Q9BYX4	Q8R5F7
RefSeq (mRNA)	NM_022168	NM_001164477 NM_027835
RefSeq (protein)	NP_071451	NP_001157949.1 NP_082111.2 NP_001157949 NP_082111
Location (UCSC)	Chr 2: 162.27 – 162.32 Mb	Chr 2: 62.6 – 62.65 Mb
PubMed search

2RQB, 3B6E, 3GA3, 4GL2

64135

71586

ENSG00000115267

ENSMUSG00000026896

Q9BYX4

Q8R5F7

NM_022168

NM_001164477
NM_027835

NP_071451

NP_001157949.1
NP_082111.2
NP_001157949
NP_082111

MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length. For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2. The signaling cascades in MDA5 is initiated via CARD domain.

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Wikipedia