MCM7

MCM7
Identifiers
Aliases	MCM7, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104, minichromosome maintenance complex component 7
External IDs	MGI: 1298398 HomoloGene: 4323 GeneCards: MCM7
Gene ontology Molecular function • nucleotide binding • helicase activity • ATP-dependent DNA helicase activity • single-stranded DNA binding • DNA helicase activity • protein binding • hydrolase activity • ATP binding • DNA binding Cellular component • membrane • nucleoplasm • chromatin • nuclear chromosome, telomeric region • nucleus • MCM complex • cytosol Biological process • cellular response to organic substance • G1/S transition of mitotic cell cycle • cellular response to xenobiotic stimulus • regulation of phosphorylation • cellular response to DNA damage stimulus • cellular response to epidermal growth factor stimulus • DNA replication initiation • cell cycle • cell proliferation • response to drug • DNA unwinding involved in DNA replication • DNA replication Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4176	17220
Ensembl	ENSG00000166508	ENSMUSG00000029730
UniProt	P33993	Q61881
RefSeq (mRNA)	NM_001278595 NM_005916 NM_182776	NM_008568
RefSeq (protein)	NP_001265524 NP_005907 NP_877577	NP_032594.1 NP_032594
Location (UCSC)	Chr 7: 100.09 – 100.1 Mb	Chr 5: 138.16 – 138.17 Mb
PubMed search

4176

17220

ENSG00000166508

ENSMUSG00000029730

P33993

Q61881

NM_001278595
NM_005916
NM_182776

NM_008568

NP_001265524
NP_005907
NP_877577

NP_032594.1
NP_032594

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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Wikipedia