MCM2

MCM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UUZ, 5BNV, 5BNX, 5BO0, 5C3I, 5JA4
Identifiers
Aliases	MCM2, BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19, minichromosome maintenance complex component 2, DFNA70
External IDs	OMIM: 116945 MGI: 105380 HomoloGene: 3325 GeneCards: MCM2
Gene ontology Molecular function • DNA binding • nucleotide binding • helicase activity • histone binding • metal ion binding • DNA helicase activity • protein binding • enzyme binding • DNA replication origin binding • hydrolase activity • ATP binding Cellular component • cytoplasm • microtubule cytoskeleton • nucleoplasm • nuclear origin of replication recognition complex • chromatin • MCM complex • nuclear chromosome, telomeric region • nucleus • cytosol Biological process • cellular response to interleukin-4 • nucleosome assembly • G1/S transition of mitotic cell cycle • DNA replication • DNA replication initiation • DNA unwinding involved in DNA replication • apoptotic process • cell cycle • cochlea development • DNA duplex unwinding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4171	17216
Ensembl	ENSG00000073111	ENSMUSG00000002870
UniProt	P49736	P97310
RefSeq (mRNA)	NM_004526	NM_008564
RefSeq (protein)	NP_004517	NP_032590.2 NP_032590
Location (UCSC)	Chr 3: 127.6 – 127.62 Mb	Chr 6: 88.88 – 88.9 Mb
PubMed search

4UUZ, 5BNV, 5BNX, 5BO0, 5C3I, 5JA4

4171

17216

ENSG00000073111

ENSMUSG00000002870

P49736

P97310

NM_004526

NM_008564

NP_004517

NP_032590.2
NP_032590

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.

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Wikipedia