MCL1

MCL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KBW, 2MHS, 2NL9, 2NLA, 2PQK, 3D7V, 3IO9, 3KJ0, 3KJ1, 3KJ2, 3KZ0, 3MK8, 3PK1, 3TWU, 3WIX, 3WIY, 4BPI, 4BPJ, 4HW2, 4HW3, 4HW4, 4OQ5, 4OQ6, 4WGI, 4WMR, 4WMS, 4WMT, 4WMU, 4WMV, 4WMW, 4WMX, 4ZBF, 4ZBI, 5FDO, 5FDR, 5FC4, 5C3F
Identifiers
Aliases	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, myeloid cell leukemia 1, BCL2 family apoptosis regulator
External IDs	MGI: 101769 HomoloGene: 7413 GeneCards: MCL1
Gene ontology Molecular function • BH3 domain binding • protein binding • protein heterodimerization activity • protein channel activity Cellular component • cytoplasm • integral component of membrane • membrane • Bcl-2 family protein complex • nucleoplasm • mitochondrial outer membrane • mitochondrial matrix • mitochondrion • nucleus • cytosol Biological process • regulation of apoptotic process • cell differentiation • response to cytokine • cellular homeostasis • multicellular organism development • positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • apoptotic mitochondrial changes • extrinsic apoptotic signaling pathway in absence of ligand • cell fate determination • regulation of response to DNA damage stimulus • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of anoikis • apoptotic process • negative regulation of apoptotic process • protein transmembrane transport • negative regulation of autophagy • intrinsic apoptotic signaling pathway in response to DNA damage Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4170	17210
Ensembl	ENSG00000143384	ENSMUSG00000038612
UniProt	Q07820	P97287
RefSeq (mRNA)	NM_182763 NM_001197320 NM_021960	NM_008562
RefSeq (protein)	NP_001184249 NP_068779 NP_877495	NP_032588.1 NP_032588
Location (UCSC)	Chr 1: 150.57 – 150.58 Mb	Chr 3: 95.66 – 95.66 Mb
PubMed search

2KBW, 2MHS, 2NL9, 2NLA, 2PQK, 3D7V, 3IO9, 3KJ0, 3KJ1, 3KJ2, 3KZ0, 3MK8, 3PK1, 3TWU, 3WIX, 3WIY, 4BPI, 4BPJ, 4HW2, 4HW3, 4HW4, 4OQ5, 4OQ6, 4WGI, 4WMR, 4WMS, 4WMT, 4WMU, 4WMV, 4WMW, 4WMX, 4ZBF, 4ZBI, 5FDO, 5FDR, 5FC4, 5C3F

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