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MC1R

MC1R
Identifiers
Aliases MC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor
External IDs MGI: 99456 HomoloGene: 1789 GeneCards: MC1R
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002386

NM_008559

RefSeq (protein)

NP_002377

NP_032585.2
NP_032585

Location (UCSC) Chr 16: 89.91 – 89.92 Mb Chr 8: 123.41 – 123.41 Mb
PubMed search

NM_002386

NM_008559

NP_002377

NP_032585.2
NP_032585

The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH).

MC1R is one of the key proteins involved in regulating mammalian skin and hair color. It is located on the plasma membrane of specialized cells known as melanocytes, which produce the pigment melanin through the process of melanogenesis. It works by controlling the type of melanin being produced, and its activation causes the melanocyte to switch from generating the yellow or red phaeomelanin by default to the brown or black eumelanin in replacement.


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Wikipedia

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