MAT1

MNAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G25
Identifiers
Aliases	MNAT1, CAP35, MAT1, RNF66, TFB3, CDK activating kinase assembly factor
External IDs	MGI: 106207 HomoloGene: 1821 GeneCards: MNAT1
Gene ontology Molecular function • DNA-dependent ATPase activity • protein N-terminus binding • metal ion binding • protein binding • RNA polymerase II carboxy-terminal domain kinase activity • cyclin-dependent protein serine/threonine kinase activator activity • zinc ion binding Cellular component • nucleoplasm • nucleus • cytosol • holo TFIIH complex Biological process • termination of RNA polymerase I transcription • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of transcription, DNA-templated • protein complex assembly • adult heart development • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase I promoter • G1/S transition of mitotic cell cycle • transcription elongation from RNA polymerase II promoter • negative regulation of apoptotic process • 7-methylguanosine mRNA capping • transcription from RNA polymerase II promoter • ventricular system development • transcription, DNA-templated • response to calcium ion • transcription elongation from RNA polymerase I promoter • G2/M transition of mitotic cell cycle • cell cycle • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • cell proliferation • DNA repair • positive regulation of transcription from RNA polymerase II promoter • positive regulation of smooth muscle cell proliferation • protein phosphorylation • nucleotide-excision repair, preincision complex assembly • positive regulation of cyclin-dependent protein serine/threonine kinase activity • nucleotide-excision repair Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4331	17420
Ensembl	ENSG00000020426	ENSMUSG00000021103
UniProt	P51948	P51949
RefSeq (mRNA)	NM_001177963 NM_002431	NM_008612
RefSeq (protein)	NP_001171434 NP_002422	NP_032638
Location (UCSC)	Chr 14: 60.73 – 60.97 Mb	Chr 12: 73.12 – 73.27 Mb
PubMed search

1G25

4331

17420

ENSG00000020426

ENSMUSG00000021103

P51948

P51949

NM_001177963
NM_002431

NM_008612

NP_001171434
NP_002422

NP_032638

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.

Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'ménage à trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM]

MNAT1 has been shown to interact with:

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Wikipedia