MASP2 (gene)

MASP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4FXG, 1Q3X, 1SZB, 1ZJK, 3TVJ
Identifiers
Aliases	MASP2, MAP19, MASP-2, MASP1P1, sMAP, mannan binding lectin serine peptidase 2, Mannan-binding lectin serine protease 2
External IDs	OMIM: 605102 MGI: 1330832 HomoloGene: 4819 GeneCards: MASP2
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.22 Start 11,026,523 bp End 11,047,233 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 E2 Start 148,602,554 bp End 148,615,499 bp
Gene ontology Molecular function • calcium ion binding • peptidase activity • serine-type peptidase activity • protein binding • hydrolase activity • calcium-dependent protein binding • metal ion binding • complement component C4b binding • serine-type endopeptidase activity Cellular component • extracellular region • extracellular exosome • extracellular space Biological process • complement activation, lectin pathway • proteolysis • complement activation, classical pathway • immune system process • innate immune response • complement activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10747	17175
Ensembl	ENSG00000009724	ENSMUSG00000028979
UniProt	O00187	Q91WP0
RefSeq (mRNA)	NM_139208 NM_006610	NM_001003893 NM_010767
RefSeq (protein)	NP_006601 NP_631947	NP_001003893 NP_034897
Location (UCSC)	Chr 1: 11.03 – 11.05 Mb	Chr 1: 148.6 – 148.62 Mb
PubMed search

4FXG, 1Q3X, 1SZB, 1ZJK, 3TVJ

10747

17175

ENSG00000009724

ENSMUSG00000028979

O00187

Q91WP0

NM_139208
NM_006610

NM_001003893
NM_010767

NP_006601
NP_631947

NP_001003893
NP_034897

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene.

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