MARCO

MARCO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OY3, 2OYA
Identifiers
Aliases	MARCO, SCARA2, macrophage receptor with collagenous structure, SR-A6
External IDs	MGI: 1309998 HomoloGene: 4928 GeneCards: MARCO
Gene ontology Molecular function • scavenger receptor activity • transmembrane signaling receptor activity • signaling pattern recognition receptor activity Cellular component • integral component of membrane • endocytic vesicle membrane • plasma membrane • collagen trimer • integral component of plasma membrane • membrane Biological process • apoptotic cell clearance • cell surface receptor signaling pathway • innate immune response • endocytosis • receptor-mediated endocytosis • immune system process • pattern recognition receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8685	17167
Ensembl	ENSG00000019169	ENSMUSG00000026390
UniProt	Q9UEW3	Q60754
RefSeq (mRNA)	NM_006770	NM_010766
RefSeq (protein)	NP_006761	NP_034896.1 NP_034896
Location (UCSC)	Chr 2: 118.94 – 118.99 Mb	Chr 1: 120.47 – 120.51 Mb
PubMed search

2OY3, 2OYA

8685

17167

ENSG00000019169

ENSMUSG00000026390

Q9UEW3

Q60754

NM_006770

NM_010766

NP_006761

NP_034896.1
NP_034896

Macrophage receptor MARCO also known as macrophage receptor with collagenous structure (MARCO) is a protein that in humans is encoded by the MARCO gene.

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.

...
Wikipedia