MAPKAPK2

MAPKAPK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KWP, 1NXK, 1NY3, 2JBO, 2JBP, 2OKR, 2ONL, 2OZA, 2P3G, 2PZY, 3A2C, 3FPM, 3FYJ, 3FYK, 3GOK, 3KA0, 3KC3, 3KGA, 3M2W, 3M42, 3R2B, 3R2Y, 3R30, 3WI6, 4TYH
Identifiers
Aliases	MAPKAPK2, MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2
External IDs	MGI: 109298 HomoloGene: 56412 GeneCards: MAPKAPK2
Gene ontology Molecular function • calmodulin-dependent protein kinase activity • signal transducer activity • nucleotide binding • transferase activity • kinase activity • calcium-dependent protein serine/threonine kinase activity • calmodulin binding • ATP binding • protein binding • protein kinase activity • protein serine/threonine kinase activity • mitogen-activated protein kinase binding Cellular component • extracellular exosome • cytosol • centrosome • nucleoplasm • cytoplasm • nucleus Biological process • response to stress • MAPK cascade • regulation of mRNA stability • response to cytokine • peptidyl-serine phosphorylation • positive regulation of tumor necrosis factor biosynthetic process • G2 DNA damage checkpoint • activation of MAPK activity • cellular response to vascular endothelial growth factor stimulus • mRNA stabilization • protein autophosphorylation • 3'-UTR-mediated mRNA stabilization • cellular response to DNA damage stimulus • inner ear development • p38MAPK cascade • Ras protein signal transduction • leukotriene metabolic process • regulation of cellular response to heat • phosphorylation • protein phosphorylation • regulation of interleukin-6 production • vascular endothelial growth factor receptor signaling pathway • response to lipopolysaccharide • inflammatory response • macropinocytosis • regulation of tumor necrosis factor production • toll-like receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9261	17164
Ensembl	ENSG00000162889	ENSMUSG00000016528
UniProt	P49137	P49138
RefSeq (mRNA)	NM_004759 NM_032960	NM_008551
RefSeq (protein)	NP_004750 NP_116584	NP_032577
Location (UCSC)	Chr 1: 206.68 – 206.73 Mb	Chr 1: 131.05 – 131.1 Mb
PubMed search

1KWP, 1NXK, 1NY3, 2JBO, 2JBP, 2OKR, 2ONL, 2OZA, 2P3G, 2PZY, 3A2C, 3FPM, 3FYJ, 3FYK, 3GOK, 3KA0, 3KC3, 3KGA, 3M2W, 3M42, 3R2B, 3R2Y, 3R30, 3WI6, 4TYH

9261

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