MAPKAP1

MAPKAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VOQ
Identifiers
Aliases	MAPKAP1, JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1
External IDs	MGI: 2444554 HomoloGene: 11473 GeneCards: MAPKAP1
Gene location (Human) Chr. Chromosome 9 (human) Band 9q33.3 Start 125,437,393 bp End 125,707,234 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 34,406,771 bp End 34,624,950 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • Ras GTPase binding • phosphatidylinositol-3,5-bisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding • phosphatidic acid binding • protein binding • phosphatidylinositol-4,5-bisphosphate binding • protein kinase binding • phosphatidylinositol-3,4,5-trisphosphate binding Cellular component • Golgi apparatus • membrane • plasma membrane • nucleoplasm • cytoplasmic vesicle • nucleus • cytosol • TORC2 complex Biological process • substantia nigra development • T cell costimulation • negative regulation of Ras protein signal transduction • phosphatidylinositol-mediated signaling • establishment or maintenance of actin cytoskeleton polarity • stress-activated protein kinase signaling cascade • TORC2 signaling • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79109	227743
Ensembl	ENSG00000119487	ENSMUSG00000038696
UniProt	Q9BPZ7	Q8BKH7
RefSeq (mRNA)	NM_001006617 NM_001006618 NM_001006619 NM_001006620 NM_001006621 NM_024117	NM_001290625 NM_001290626 NM_177345
RefSeq (protein)	NP_001006618 NP_001006619 NP_001006620 NP_001006621 NP_001006622 NP_077022	NP_001277554 NP_001277555 NP_796319
Location (UCSC)	Chr 9: 125.44 – 125.71 Mb	Chr 9: 34.41 – 34.62 Mb
PubMed search

3VOQ

79109

227743

ENSG00000119487

ENSMUSG00000038696

Q9BPZ7

Q8BKH7

NM_024117

NM_001290625
NM_001290626
NM_177345

NP_077022

NP_001277554
NP_001277555
NP_796319

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.

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