MAPK12

MAPK12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CM8, 4QUM
Identifiers
Aliases	MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3, ERK-6, MAPK 12, mitogen-activated protein kinase 12
External IDs	MGI: 1353438 HomoloGene: 55705 GeneCards: MAPK12
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • metal ion binding • kinase activity • protein binding • ATP binding • magnesium ion binding • protein serine/threonine kinase activity • MAP kinase activity Cellular component • cytosol • mitochondrion • nucleoplasm • nucleus • cytoplasm Biological process • regulation of transcription, DNA-templated • phosphorylation • positive regulation of muscle cell differentiation • muscle organ development • negative regulation of cell cycle • transcription, DNA-templated • positive regulation of peptidase activity • protein phosphorylation • vascular endothelial growth factor receptor signaling pathway • peptidyl-serine phosphorylation • cell cycle arrest • DNA damage induced protein phosphorylation • cell cycle • myoblast differentiation • signal transduction • MAPK cascade • regulation of gene expression • intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6300	29857
Ensembl	ENSG00000188130	ENSMUSG00000022610
UniProt	P53778	O08911
RefSeq (mRNA)	NM_002969 NM_001303252	NM_013871
RefSeq (protein)	NP_001290181 NP_002960	NP_038899.1 NP_038899
Location (UCSC)	Chr 22: 50.25 – 50.26 Mb	Chr 15: 89.13 – 89.14 Mb
PubMed search

1CM8, 4QUM

6300

29857

ENSG00000188130

ENSMUSG00000022610

P53778

O08911

NM_002969
NM_001303252

NM_013871

NP_001290181
NP_002960

NP_038899.1
NP_038899

Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.

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