MAP1LC3B

MAP1LC3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V49, 2LUE, 2ZJD, 3VTU, 3VTV, 3VTW, 3WAO, 3X0W, 4WAA, 5D94, 5DCN
Identifiers
Aliases	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta
External IDs	MGI: 1914693 HomoloGene: 69359 GeneCards: MAP1LC3B
Gene location (Human) Chr. Chromosome 16 (human) Band 16q24.2 Start 87,383,995 bp End 87,404,779 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E1 Start 121,590,361 bp End 121,598,760 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • ubiquitin protein ligase binding Cellular component • cytoplasm • organelle membrane • membrane • intracellular • mitochondrion • axoneme • microtubule • cytoskeleton • cytoplasmic vesicle • endomembrane system • autophagosome membrane • cytosol • autophagosome Biological process • membrane organization • autophagy of mitochondrion • autophagosome assembly • autophagy • cellular response to nitrogen starvation • cellular response to starvation • macroautophagy • autophagosome maturation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81631	67443
Ensembl	ENSG00000140941	ENSMUSG00000031812
UniProt	Q9GZQ8	Q9CQV6
RefSeq (mRNA)	NM_022818	NM_026160
RefSeq (protein)	NP_073729	NP_080436
Location (UCSC)	Chr 16: 87.38 – 87.4 Mb	Chr 16: 121.59 – 121.6 Mb
PubMed search

1V49, 2LUE, 2ZJD, 3VTU, 3VTV, 3VTW, 3WAO, 3X0W, 4WAA, 5D94, 5DCN

81631

67443

ENSG00000140941

ENSMUSG00000031812

Q9GZQ8

Q9CQV6

NM_022818

NM_026160

NP_073729

NP_080436

Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes.

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