MAP1B

MAP1B
Identifiers
Aliases	MAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B
External IDs	MGI: 1306778 HomoloGene: 38111 GeneCards: MAP1B
Genetically Related Diseases
attention deficit hyperactivity disorder
Gene ontology Molecular function • microtubule binding • structural molecule activity • protein binding Cellular component • cell projection • postsynaptic density • plasma membrane • dendritic spine • photoreceptor outer segment • synapse • microtubule associated complex • cell junction • microtubule • cytoskeleton • cytoplasm • cytosol Biological process • negative regulation of intracellular transport • axonogenesis • dendrite development • nervous system development • microtubule bundle formation • axon extension • positive regulation of axon extension • mitochondrion transport along microtubule • establishment of monopolar cell polarity • cellular process • microtubule cytoskeleton organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4131	17755
Ensembl	ENSG00000131711	ENSMUSG00000052727
UniProt	P46821	P46821 P14873
RefSeq (mRNA)	NM_005909 NM_032010 NM_001324255	NM_008634
RefSeq (protein)	NP_001311184 NP_005900	NP_001311184 NP_005900 NP_032660.2 NP_032660
Location (UCSC)	Chr 5: 72.11 – 72.21 Mb	Chr 13: 99.42 – 99.52 Mb
PubMed search

4131

17755

ENSG00000131711

ENSMUSG00000052727

P46821

P46821
P14873

NM_005909
NM_032010
NM_001324255

NM_008634

NP_001311184
NP_005900

NP_001311184
NP_005900
NP_032660.2
NP_032660

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.

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Wikipedia