MAGOH

MAGOH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7
Identifiers
Aliases	MAGOH, MAGOH1, MAGOHA, mago homolog, exon junction complex core component
External IDs	MGI: 1330312 HomoloGene: 1776 GeneCards: MAGOH
Gene ontology Molecular function • protein binding • RNA binding Cellular component • cytoplasm • nuclear speck • catalytic step 2 spliceosome • exon-exon junction complex • nucleoplasm • spliceosomal complex • nucleus Biological process • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA transport • mRNA processing • regulation of alternative mRNA splicing, via spliceosome • mRNA export from nucleus • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • mRNA 3'-end processing • regulation of translation • RNA splicing • RNA export from nucleus • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4116	17149
Ensembl	ENSG00000162385	ENSMUSG00000028609
UniProt	P61326	P61327
RefSeq (mRNA)	NM_002370	NM_001282737
RefSeq (protein)	NP_002361	NP_001269666
Location (UCSC)	Chr 1: 53.23 – 53.24 Mb	Chr 4: 107.88 – 107.89 Mb
PubMed search

1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7

4116

17149

ENSG00000162385

ENSMUSG00000028609

P61326

P61327

NM_002370

NM_001282737

NP_002361

NP_001269666

Protein mago nashi homolog is a protein that in humans is encoded by the MAGOH gene.

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

MAGOH has been shown to interact with RBM8A and NXF1. In Drosophila melanogaster, Mago Nashi and Tsunagi/Y14 (core components of the exon junction complex) form a complex with a novel zinc finger protein, Ranshi, that has a role in oocyte differentiation.

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