MAF1 (gene)

MAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NR5
Identifiers
Aliases	MAF1, MAF1 homolog, negative regulator of RNA polymerase III
External IDs	MGI: 1916127 HomoloGene: 49867 GeneCards: MAF1
Gene ontology Molecular function • RNA polymerase III type 1 promoter DNA binding • GABA receptor binding • RNA polymerase III core binding • RNA polymerase III type 2 promoter DNA binding • RNA polymerase III type 3 promoter DNA binding Cellular component • cytoplasm • cytosol • intracellular membrane-bounded organelle • plasma membrane • inhibitory synapse • intracellular • axon • dendrite • nucleolus • perinuclear region of cytoplasm • nucleus • centrosome • nucleoplasm Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of transcription from RNA polymerase III promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84232	68877
Ensembl	ENSG00000179632	ENSMUSG00000022553
UniProt	Q9H063	Q9D0U6
RefSeq (mRNA)	NM_032272	NM_001164607 NM_001164608 NM_026859
RefSeq (protein)	NP_115648	NP_001158079.1 NP_001158080.1 NP_081135.3 NP_001158079 NP_001158080 NP_081135
Location (UCSC)	Chr 8: 144.1 – 144.11 Mb	Chr 15: 76.35 – 76.35 Mb
PubMed search

3NR5

84232

68877

ENSG00000179632

ENSMUSG00000022553

Q9H063

Q9D0U6

NM_032272

NM_001164607
NM_001164608
NM_026859

NP_115648

NP_081135

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.

This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.

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