Luteinizing hormone beta polypeptide

LHB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M92
Identifiers
Aliases	LHB, CGB4, LSH-B, hHH23, Luteinizing hormone beta polypeptide, LSH-beta, Luteinizing hormone subunit beta
External IDs	MGI: 96782 HomoloGene: 81806 GeneCards: LHB
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 49,015,980 bp End 49,017,081 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 29.3 cM Start 45,420,820 bp End 45,421,897 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • hormone activity Cellular component • Golgi lumen • extracellular region • extracellular exosome • extracellular space • cytoplasm Biological process • cell-cell signaling • progesterone biosynthetic process • male gonad development • peptide hormone processing • signal transduction • hormone-mediated signaling pathway • ovulation • regulation of receptor activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3972	16866
Ensembl	ENSG00000104826	ENSMUSG00000100916
UniProt	P01229	O09108
RefSeq (mRNA)	NM_000894	NM_008497
RefSeq (protein)	NP_000885	NP_032523
Location (UCSC)	Chr 19: 49.02 – 49.02 Mb	Chr 19: 45.42 – 45.42 Mb
PubMed search

1M92

3972

16866

ENSG00000104826

ENSMUSG00000100916

P01229

O09108

NM_000894

NM_008497

NP_000885

NP_032523

Luteinizing hormone subunit beta also known as lutropin subunit beta or LHβ is a polypeptide that in association with an alpha subunit common to all gonadotropin hormones forms the reproductive signaling molecule luteinizing hormone. In humans it is encoded by the LHB gene.

The luteinizing hormone beta subunit is encoded by a single gene in all mammals. In primates, this gene is located within a cluster that arose through gene duplication, and also includes multiple redundant genes encoding the beta subunit of chorionic gonadotropin as well as several nonfunctional pseudogenes. In humans these are contiguous on chromosome 19q13.3. In equids the beta subunit polypeptides of luteinizing hormone and chorionic gonadotropin are identical in sequence, differing only in their carbohydrate side-chains, and are the product of a single gene.

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