Lucius Catilius Severus Julianus Claudius Reginus was a Roman senator during the reigns of Trajan and Hadrian. He was appointed Roman consul twice, in the years 110 CE (as consul suffectus) and 120 CE (as consul ordinarius).
Catilius is called Lucius Catilius Severus Julianus in Bithynian inscriptions, Lucius Catilius Severus as a consul, and Catilius Severus in literary sources. The family origins of Catilius probably lie in Apamea, a town of Bithynia. Salomies notes that his polyonymous name implies an adoption, "no doubt the son of a Cn. Catilius, not the son of a Cn. Claudius adopted by a L. Catilius, in spite of the existence of senatorial Cn. Claudii Severi from Asia Minor."
Following his term as suffect consul, Catilius was governor of Cappadocia-Armenia from 114 through 117, then in the Fall of 117, after ascending to the purple Hadrian appointed Catilius to replace him as governor of Syria where Catilius remained into 119. After sharing the fasces with Antoninus Pius in 120, Catilius held the proconsulship of Africa in 124/125. He was also prefect of Rome.
Catilius is believed to have married Dasumia Polla, the widow of Domitius Tullus, and thereby became step-great-grandfather of the later Emperor Marcus Aurelius, whose upbringing he influenced. Two Gnaei Catilii Severi, attested as members of the Arval Brethren in 183 and 213-8, were doubtlessly the descendants of Catilius, or at the least from his family.