Gnaeus Calpurnius Piso (Latin: Cn. Calpurnius Cn. f. Cn. n. Piso, ca. 44 BC/43 BC - AD 20), was a Roman statesman during the reigns of Augustus and Tiberius. He was consul in 7 BC; subsequently, he was governor of Hispania and proconsul of Africa. He belonged to one of Rome's most distinguished Senatorial families, whose members included Calpurnia, third wife of Julius Caesar.
He was a member of the gens Calpurnia, specifically among the Calpurnii Pisones. His father and grandfather both shared his name, with his father being Gnaeus Calpurnius Piso (consul in 23 BC), and his grandfater being one of the participants in the Catiline Conspiracy. He had a brother, Lucius Calpurnius Piso, who was an augur and became consul in 1 BC.
Piso had two sons, Lucius Calpurnius Piso (born Gnaeus), and Marcus Calpurnius Piso.
Piso held many positions under Augustus and Tiberius. He was in charge of the imperial mint and in 7 BC he was made consul with Tiberius, and was sent by Augustus as legate to Hispania.
In 3 BC he was proconsul of the province Africa, and of Hispania Tarraconensis in AD 9. According to Tacitus, he was cruel to the people of Spain, but during his trial in AD 20 such claims were discounted as "old and irrelevant".
Though he was given may appointments throughout his career, he was known to have a temper. In AD 16, he argued against Tiberius that the senate should be able to conduct business without the emperor if the emperor was away from Rome. It was only after a lengthy debate between Piso and senators close to Tiberius that he lost the debate.