Louise Marguerite of Lorraine (1588 – 30 April 1631) was a daughter of the Duke of Guise and a member of the House of Lorraine. She married François de Bourbon, titled the Prince of Conti. As such, after her marriage she was the Princess of Conti. She died without any surviving issue.

Louise Marguerite was born at the Château de Blois, present at Blois outside Paris. Her father was Henri of Lorraine, Duke of Guise and member of the House of Lorraine. She was the penultimate child of fourteen; her brother Claude, Duke of Chevreuse was the husband of Marie de Rohan, the infamous Frondeur. Her oldest brother Charles was the last Duke of Guise after the death of her father in 1588.

She was a member of the house of Guise, a cadet branch of the house of Lorraine which was the ruling family of the Duchy of Lorraine and Bar. As a Lorraine, she was a Foreign Princess at the French court.

She was named after her two godmothers; Louise in honour of Louise of Lorraine, wife of Henry III of France and Marguerite in honour of Marguerite de Valois, first wife of Henry IV. She grew up in the care of her mother and paternal grandmother, Anna d'Este.

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