Louis-Antoine Dessaulles (1818 – August 4, 1895) was a Quebec seigneur, journalist and political figure.
He was born in Saint-Hyacinthe, Lower Canada in 1818, the son of Jean Dessaulles, and studied at the Collège de Saint-Hyacinthe and the Petit Séminaire de Montréal. He studied law at Montreal, staying there with his uncle, Louis-Joseph Papineau; he helped Papineau escape from Montreal in November 1837. He travelled with Papineau's wife to Paris in 1839.
In 1835, Dessaulles had inherited the seigneury of Saint-Hyacinthe from his father. In 1844, he ran unsuccessfully against Thomas Boutillier to represent Saint-Hyacinthe in the legislative assembly. In 1847, Dessaulles began writing articles for the newspaper L'Avenir; he supported Papineau, opposed the political power of the Roman Catholic Church in Canada East, opposed the union of Upper and Lower Canada and supported annexation with the United States. He was mayor of Saint-Hyacinthe from 1849 to 1857. Dessaulles was editor for the Montreal paper Le Pays in its early days during the 1850s and again in 1861. In 1856, he was elected to the Legislative Council of the Province of Canada for Rougemont division. He spoke in favour of a decentralized federation. Dessaulles served several terms as president of the Institut canadien de Montréal. In 1863, he was appointed clerk of the crown and clerk of the peace; at that time, he resigned his seat on the legislative council and his editorship of Le Pays.