"Lose My Breath" is a song by American group Destiny's Child. It was written by Beyoncé, Kelly Rowland, Michelle Williams, Rodney "Darkchild" Jerkins, LaShawn Daniels, Fred Jerkins III, Sean Garrett, and Shawn Corey "Jay-Z" Carter for the group's fourth studio album, Destiny Fulfilled (2004). Columbia Records released "Lose My Breath" as the first single from the album in late 2004. The song was partially developed by Jerkins before being presented to Destiny's Child and its chorus was afterwards written by Jay-Z.

An uptempo R&B and dance-pop song, "Lose My Breath" has a marching, military percussion-led instrumentation with different sound effects in its backing track. It received positive reviews from music critics who generally praised its melody and instrumentation. The track further received a Grammy Award nomination in the category for Best R&B Vocal Performance by a Duo or Group. "Lose My Breath" was commercially successful peaking at number three on the US Billboard Hot 100 and reaching the top spot on many charts in Europe as well as appearing in the top ten in almost every chart.

The single's music video directed by Marc Klasfeld and filmed in Los Angeles, California, featured Destiny's Child performing dance choreographies portraying three different characters. The song was performed during the group's tour Destiny Fulfilled... and Lovin' It (2005) and on numerous televised appearances and awards ceremonies in 2004 and 2005. The American Broadcasting Company used "Lose My Breath" as the official song for the NBA playoffs in 2004 and 2005.

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