Prince Lorenzo Onofrio Colonna (1637–1689) was an Italian nobleman of the Colonna family. He was the 8th Duke and Prince of Paliano and hereditary Grand Constable of the Kingdom of Naples. He was also a Knight of the Golden Fleece.
Colonna was born in Rome, the son of Marcantonio V Colonna, Prince of Paliano and Isabella Gioeni Cardona, Princess of Castiglione. He was the nephew of Anna Colonna who married Taddeo Barberini, Prince of Palestrina. He was inducted into the Order of the Golden Fleece in the same year as his cousin, Maffeo Barberini.
In 1661 he married Maria Mancini, a niece of Cardinal Mazarin. She was the first love of Louis XIV whose desire to marry her caused his mother, Anne of Austria, and Maria's uncle intense concern. The relationship between Maria and Louis was an idealistic one, and remained unconsummated. Colonna remarked after their wedding night that he was surprised to find her still a virgin, famously stating that had not expected to find "innocence among the loves of kings."
He and his wife became great patrons of the arts, and exercised influence in the cultural and political spheres of Rome and Italy. Many artists such as Nicolò Minato and Francesco Cavalli dedicated works to the Colonnas. Despite Colonna's prestigious French marriage, the Colonna family was generally aligned with Spanish interests in Italy. The family's rivals in Rome, the Orsini and Barberini were French partisans.