The Lopasnya River (Russian: Лопа́сня) is a river in Moscow Oblast in Russia. It is a left tributary of the Oka. It is 108 km in length, with a drainage basin of 1090 km². Its average discharge is 6,76 m³/s.
Coordinates: 54°50′34″N 37°51′00″E / 54.8427°N 37.8500°E