Lockdown (2010) was a professional wrestling pay-per-view (PPV) event produced by the Total Nonstop Action Wrestling (TNA) promotion, which took place on April 18, 2010 at the Family Arena in Saint Charles, Missouri. It was the sixth event under the Lockdown chronology and the fourth event of the 2010 TNA PPV schedule. In the tradition of Lockdown events, every match took place inside a steel cage. It was the first Lockdown event with a four-sided steel cage.

The sixth installment to the Lockdown PPV chronology was first announced in a press release on January 16, 2010 regarding the February Against All Odds PPV event. The date and area of the event was not announced until February 4, 2010, when another press release proclaimed that it would take place on April 18, 2010 at the Family Arena in Saint Charles, Missouri. A tradition of the series is that all encounters take place inside a steel cage which will be continued. On January 17, 2010 at their Genesis PPV event, TNA discontinued the usage of their normal six sided ring, with a four sided ring being chosen instead. It was the first Lockdown to feature the traditional four-sided cage.

Lockdown featured nine professional wrestling matches that involved different wrestlers from pre-existing scripted feuds and storylines. Wrestlers portrayed villains, heroes, or less distinguishable characters in the scripted events that built tension and culminated in a wrestling match or series of matches.

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