Liver X receptor beta

NR1H2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P8D, 1PQ6, 1PQ9, 1PQC, 1UPV, 1UPW, 3KFC, 3L0E, 4DK7, 4DK8, 4RAK, 5HJP, 4NQA, 5I4V,%%s4NQA
Identifiers
Aliases	NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR, Liver X receptor beta, nuclear receptor subfamily 1 group H member 2
External IDs	MGI: 1352463 HomoloGene: 21397 GeneCards: NR1H2
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 50,329,653 bp End 50,382,982 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B3 Start 44,549,616 bp End 44,553,951 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • ATPase binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding • metal ion binding • retinoid X receptor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • steroid hormone receptor activity • apolipoprotein A-I receptor binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • protein binding Cellular component • cytoplasm • nucleoplasm • nucleus Biological process • positive regulation of high-density lipoprotein particle assembly • negative regulation of proteolysis • regulation of cholesterol homeostasis • positive regulation of triglyceride biosynthetic process • positive regulation of cellular protein metabolic process • negative regulation of interferon-gamma-mediated signaling pathway • positive regulation of cholesterol transport • regulation of transcription, DNA-templated • cellular lipid metabolic process • regulation of transcription from RNA polymerase II promoter • positive regulation of secretion of lysosomal enzymes • positive regulation of lipid storage • positive regulation of lipoprotein lipase activity • negative regulation of transcription from RNA polymerase II promoter • positive regulation of fatty acid biosynthetic process • negative regulation of gene expression • transcription, DNA-templated • positive regulation of transcription, DNA-templated • negative regulation of cholesterol storage • negative regulation of pinocytosis • positive regulation of gene expression • retinoic acid receptor signaling pathway • positive regulation of cholesterol efflux • positive regulation of pancreatic juice secretion • lipid homeostasis • cholesterol homeostasis • negative regulation of lipid transport • transcription initiation from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • negative regulation of macrophage derived foam cell differentiation • positive regulation of transcription from RNA polymerase II promoter • steroid hormone mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7376	22260
Ensembl	ENSG00000131408	ENSMUSG00000060601
UniProt	P55055	Q60644
RefSeq (mRNA)	NM_007121 NM_001256647	NM_001285517 NM_001285518 NM_001285519 NM_009473
RefSeq (protein)	NP_001243576 NP_009052 NP_009052.3	NP_001272446 NP_001272447 NP_001272448 NP_033499
Location (UCSC)	Chr 19: 50.33 – 50.38 Mb	Chr 19: 44.55 – 44.55 Mb
PubMed search

1P8D, 1PQ6, 1PQ9, 1PQC, 1UPV, 1UPW, 3KFC, 3L0E, 4DK7, 4DK8, 4RAK, 5HJP, 4NQA, 5I4V,%%s4NQA

7376

22260

ENSG00000131408

ENSMUSG00000060601

P55055

Q60644

NM_007121
NM_001256647

NM_001285517
NM_001285518
NM_001285519
NM_009473

...
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